Do not start, stop or change the dosage of any medicine before checking with them first. It naturally occurs in black tea, and is degraded by the liver to caffeine. Evolution of drug metabolism as a science richard tecwyn williams great britain 1942, worked on the metabolism on tnt with regard to toxicity in munitions workers. Theophylline oral interactions with other medication. A drug interaction is an interaction between a drug and some other substance, such as another drug or a certain type of food, which prevents the drug from. Taking theophylline extendedrelease tablets immediately after ingesting a high fat content meal 45 g fat, 55 g carbohydrates, 28 g protein, 789 calories may result in a somewhat higher c max and delayed t max and a somewhat greater extent of absorption when compared to taking it in the fasting.
Theophylline drug interactions can alter the level of theophylline in your blood or make some drugs less effective, among other things. Amnesic syndrome after theophylline associated seizures. Johns wort can decrease the level of theophylline in your blood, perhaps making it less effective. If you are taking these drugs together, your healthcare provider may need to adjust your theophylline dosage. Applied pharmaceutical practice christopher a langley senior lecturer in pharmacy practice aston university school of pharmacy, birmingham, uk and dawn belcher teaching fellow, pharmacy practice, aston university school of pharmacy, birmingham, uk london chicago app prelims 22808 1. This study is created by ehealthme based on reports of 12 people who take fluoxetine hydrochloride and theophylline from food and drug administration fda, and is updated regularly. Pdr drug summaries are concise pointofcare prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice pdr s drug summaries are available free of charge and serve as a great resource for us based mds, dos, nps and pas in patient practice. Online store how to order refill order contact us faqs. Alcohol, quinidine, and warfarin may potentially cause drug interactions with phenytoin. Never use theophylline in larger amounts, or for longer than prescribed. Oxcarbazepine has fewer drug interactions than carbamazepine, and gabapentin has one, a.
See what the interactions are and for which people. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Drug interactions are reported among people who take theophylline and alcohol together. This document does not contain all possible drug interactions. Latest news democratic rep says hydroxychloroquine, trump helped save her life amid covid19 fight. Dailymed theophylline anhydrous theophylline tablet. Whatever the mechanism, the interaction may be sufficient to necessitate adjustment of the theophylline dosage. Johns wort without first talking with your healthcare provider. Drug interactions are reported among people who take fluoxetine hydrochloride and theophylline together. Subsequently theophylline concentrations were found to parallel a number of changes in fluvoxamine dosage see reference number 7. Plasmatheophylline concentration is measured 5 days after starting oral treatment and at least 3 days after any dose adjustment. Theophylline is an older drug used to treat asthma or copd, it works as a bronchodilator. Many drugs interact with theophylline by inhibiting or potentiating its metabolism by cyp1a2 see commonlyused drugs that interact with theophylline.
Drug interactions and adverse drug effects are responsible for the. Theophylline generic drug search results polarmeds. Its used to treat airflow obstruction symptoms such as wheezing, shortness of breath, and chest. Learn who its for, how it works, its side effects, warnings, and more. This may reduce the effectiveness of the medication. The molecular formula of anhydrous theophylline is c 7 h 8 n 4 o 2 with a molecular weight of 180. Drug interactions with theophylline may demand dosage. Theophylline may also be used for purposes not listed in this medication guide. During treatment with theophylline, do not start or stop taking st. Whatever the mechanism, the interaction may be sufficient to necessitate adjustment of the theophylline dosage, preferably. National institutes of healthfunded general clinical research center.
Evaluated prevalence and characteristics of adrs from drug interactions 1014 adrs analyzed 912 of the adrs had direct drug interactions 31% considered major most were hemorrhages 54% warfarin was most common drug involved. Drug interactions with erythromycin oral and theophylline oral. Fall of total drug level accommodates rise in free fraction % freetotal concentration with minimal pharmacodynamic effect. Theophylline interactions learning article pharmaceutical. Theophylline interactions bnf content published by nice. Taking theophylline with propranolol can greatly increase the level of theophylline in your blood, which can cause dangerous side effects. Theophylline interacts with a wide variety of drugs. Drug interactions with theophylline may demand dosage adjustment. Theophylline complete drug information, side effects and. Pharmacokinetic interactions between theophylline and other. Lanophyllin intravenous interactions with other medication. Theophylline and alcohol drug interactions a study of fda. Seek medical attention if your breathing problems get worse. C are at risk for cytochrome cyp p450 drug interactions when they are admitted to or discharged from a smoke free facility.
Pharmacokinetic interactions between theophylline and other medication part i. Theophylline elixophyllin, theo24 is a bronchodilator prescribed for the treatment of asthma and other airway conditions. Effect of the addition of ciprofloxacin on theophylline. Common drug interactions boca raton regional hospital. At least one manufacturer suggests dosage of approximately 0. To get started, click the add search condition button to select your first field. Drug interactions checker medscape drug reference database.
See what others have said about theophylline, including the effectiveness, ease of use and side effects. Although we attempt to provide accurate and uptodate information, no guarantee is made to that effect. Many drugs have been found to increase or decrease the clearance of theophylline, probably by interaction with one or more of the variants of the cytochrome p450 drug metabolising system. Theophylline, anhydrous oral tablet, extended release drug. Theophylline, anhydrous oral tablet, extended release drug summary. Theophylline uniphyl and theo24 side effects, dosage.
Dec, 2012 since up to 90% of a theophylline dose is biotransformed, drugs influencing microsomal enzyme systems in the liver may affect the elimination of theophylline. The drug aminophylline differs somewhat in its structure from theophylline in that it contains ethylenediamine, as well as more molecules of water. The drug is metabolised in the liver by cytochrome p450 isoenzymes, principally cyp1a2, to demethylated and hydroxylated products. This study is created by ehealthme based on reports of 186 people who take levofloxacin and theophylline from food and drug administration fda, and is updated regularly. Before using theophylline, ephedrine, and phenobarbital. Theophylline, also known as 1,3dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease copd and asthma under a variety of brand names. Theophylline is now usually used as an addon therapy in asthma patients not well controlled on inhaled. In a randomized crossover sequence, subjects received theophylline 5 mgkg on day 6 of therapy with cimetidine 2400 mgd, ciprofloxacin 1 gd, both drugs, or while drug free.
Theophylline toxicity, mainly iatrogenic, can cause seizures in patients without known underlying epilepsy. Theophylline is a widely used bronchodilator and a very potent central nervous system cns stimulant. Theophylline, ephedrine, and phenobarbital advanced. Pharmacokinetic drug interactions with theophylline. This study is created by ehealthme based on reports of 186 people who take levofloxacin and theophylline from food and drug administration fda, and is. To minimize potential for interaction, you may interrupt the feeding for one hour before and one hour after the theophylline dose. Do not take theophylline if you are addict of tobacco, cannabis and alcohol. Products containing theophylline, ephedrine, and phenobarbital were withdrawn from the u. Refer to precautions, drug interactions for information regarding table.
You can build up queries that support a wide range of conditions and predicates. Taking theophylline with certain antibiotics can increase the level of theophylline in your blood, which can cause dangerous side effects. Interactions between lanophyllin oral and theophyllines. The most common types of seizures are generalized and partial seizures with secondary generalization,151,152 but status epilepticus can occur in approximately 30% of patients. If you are taking these drugs together, your healthcare provider should monitor the level of theophylline in your blood and adjust your theophylline dosage as necessary. Please check with a physician if you have health questions or concerns. Drug interactions with fluvoxamine oral and theophylline oral. Drug interactions with phenytoin nervous system home page. Learn about theophylline from patients first hand experiences and trusted online health resources, including dosage, side effects and interactions. Selected herb drug interactions herb common use may interact with potential effect alfalfa medicago sativa multiple, including treatment of arthritis, asthma, dyspepsia, hyperlipidemia, and diabetes anticoagulants 1,2 alfalfa contains coumarin constituents and vitamin k. Theophylline is the generic name for the prescription drugs uniphyl in canada and theo24.
Caffeinecontaining herbs such as cola nut, guarana, mate. Many drugs have been found to increase or decrease the clearance of theophylline, probably by interaction with one or more of the variants of the cytochrome p450 drug. Theophylline comes as an extendedrelease longacting tablet, extendedrelease capsule, and a solution liquid to take by mouth. Theophylline is an oral medication used to treat asthma and other lung diseases. The dose of ciprofloxacin is also effectively decreased. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in nature, being present in tea camellia. To include fields in the results that you dont want to search, click add display field below. Selected herbdrug interactions university of michigan.
Pdf amnesic syndrome after theophylline associated seizures. Drug interactions theophylline interacts with a wide variety of drugs. We would like to show you a description here but the site wont allow us. Theophylline prescription drug information, interactions. Most common drug drug interactions marengoni study. Dailymed theophylline theophylline anhydrous solution. Pharmacokinetic interactions between theophylline and. Somophyllin interactions somophyllin interacts with a wide variety of drugs. It requires monitoring of drug levels so is not often used anymore except in difficult to manage cases. This tool may not cover all possible drug interactions.
Drug interactions may change how your medications work or increase your risk for serious side effects. Drug interactions are reported among people who take levofloxacin and theophylline together. This study is created by ehealthme based on reports of 26 people who take theophylline and alcohol from food and drug administration fda, and is updated regularly. Drug interactions a drug may affect the activity of another by altering its metabolism. Cipro iv ciprofloxacin dose, indications, adverse effects. Theophylline is a bronchodilator that is used to treat symptoms of asthma, bronchitis, emphysema, and other breathing problems. Advanced search provides a powerful interface for searching the database. This page on the emedtv web site explains what other drugs may cause phenytoin interactions and describes the possible risks of combining them with phenytoin. Probably the most important of such interactions are those resulting in inhibition of phenytoin metabolism. Both aminophylline and theophylline are methylxanthines and are derived from the group called xanthines. Fluoxetine hydrochloride and theophylline drug interactions. All interactions with theophylline slophyllin, theodur coadministered drug dose of drug dose of theophylline. This drug drug interaction may cause you to experience an unexpected side effect. Levofloxacin and theophylline drug interactions a study.
Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. Now in its twelfth edition, stockleys drug interactions is still the most comprehensive and authoritative international source of drug interaction information. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. To reduce the risk of developing potentially dangerous drug interactions with theophylline, you should talk with your healthcare provider or pharmacist about any theophylline interactions that may apply to you. Drug interactions with phenytoin are a frequent occurrence, although their clinical relevance has often been overemphasised. Pdf drug interactionsprinciples, examples and clinical.
Dailymed theophylline theophylline, anhydrous capsule. Theophylline definition of theophylline by medical dictionary. When theophylline is given with enteral tube feedings, blood levels may be decreased due to interference with its absorption. A 70yearold man similarly developed theophylline toxicity,with theophylline levels of about 32 mgl reference range 10 to 20 mgl, when fluvoxamine was added. Cs medications are substrates of cyp1a2 acetaminophen, caffeine, cyclobenzaprine, diazepam, duloxetine. A blood sample should usually be taken 46 hours after an oral dose of a modifiedrelease preparation sampling times may varyconsult local guidelines. Theophylline, anhydrous oral tablet, extended release 24 hour drug summary. Theophylline free drug price comparison free rx coupons. Since up to 90% of a theophylline dose is biotransformed, drugs influencing microsomal enzyme systems in the liver may affect the elimination of theophylline. Theophylline, anhydrous oral tablet, extended release 24 hour. The aim of stockleys drug interactions is to inform busy doctors, pharma cists, surgeons. All interactions with theophylline slophyllin, theodur coadministered drug dose of drug dose of theophylline effect on drug levels effect on theophylline levels potential clinical effects mechanism of interaction management. These substances may show some reactions with theophylline.
A bronchodilator, aminophylline is a derivative of theophylline. Levofloxacin and theophylline drug interactions a study of. Use the search field above to look up prescription or otc drugs, and herbal supplements. Handbook of drug interactions a clinical and forensic guide. Theophylline drug, uses, dose, tablets, side effects.
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